After years of review of reports of hundreds of ibogaine patient treatments, the effective dose for the treatment of chemical dependence, including opioid dependence, has been seen to be between 15 mg/kg and 20 mg/kg of ibogaine. It has been reported by some researchers that lower doses are effective but, this has been disputed. Effects of ibogaine generally will make themselves evident within 45 minutes to as long as, three hours after administration. In most cases opioid withdrawal signs will be reduced within 45 minutes of ibogaine administration. Ibogaine is usually administered in place of what would be the next scheduled dose of narcotics. This would provide for an ibogaine administration schedule 8 hours after the last dose of heroin, morphine or demerol and 24 hours after the last dose of methadone. It is expected that the patient would be exhibiting minor withdrawal signs at the time of ibogaine administration.
Once ibogaine has been administered, effects follow. The patient will usually want to lay prone and should be encouraged to remain still as nausea and vomiting as well as, being systemic have been seen to be motion related. The skin tends to become numb. Patients will report an initial buzzing or oscillating sound. A period of dream-like visualization lasting for 3 to 4 hours in most but, not all patients is considered to be the first prominent stage of ibogaine effects. This stage ends abruptly should it occur at all. Another aspect of ibogaine effect that is common are random flashes of light that appear everywhere with eyes open. This may last for hours or days. Visualization on the other hand is most common with eyes closed.
The second stage
A stage described as one in which the subject principally experiences cognitive evaluation or a review of issues that are important to the subject. These may cover every possible scenario from early childhood experiences to current health issues. This period may last for as few as 8 hours or for 20 hours or longer.
The third or final stage
A stage of ibogaine effects is that of residual stimulation. This stage, because it tends to leave the subject/patient exhausted is somewhat uncomfortable. Subjects may remain awake for two or more days. Most patients will sleep within 48 hours of ibogaine administration. Some within 24 hours of administration. Usually, there is a long term long term diminishment of the need for sleep over weeks or months. Some patients may require or request sedation. Sedatives that have been used include benzodiazepines, barbiturates and melatonin.
It stimulates what have been described as “oneirogenic” effects, meaning that it generates a waking dream state. These effects have been described as very similar to dream-like visions in both quality and content.
The therapeutic doses of ibogaine that we use in the detoxification process may last as long as 24-48 hours. Everybody’s individual experience is unique, however there are some common elements that many people share. What seems most common is that the experience is profoundly meaningful. And that it is healing and beneficial and healing on all levels of the body and psyche.
As ibogaine passes through the blood stream the liver begins to convert it into a metabolite called nor-ibogaine. Nor-ibogaine is said to have many similar effects to ibogaine, but it has a much longer half-life in the body. Researchers estimate that nor-ibogaine can remain in the body for a period of days to weeks after the treatment. May also be at least partially responsible for the long-term reduction in cravings that follow.
Another noticeable long-term effect is that ibogaine therapy stimulates the secretion of <em>glial cell derived neurotrophic factor</em>, or GDNF, which is a protein that generates the growth of new dopamine neurons. The effects of GDNF are so pronounced in their repair of the dopamine system that ibogaine has shown promise as a potential therapy for Parkinson’s disease. The same dopamine repair is notable for addiction detox because the growth of new dopamine neurons provides an opportunity to repair and rewire the brain’s desire and reward system.